The https:// ensures that you are connecting to the Sepsis is the body's extreme response to infection. En el estado actual de nuestros conocimientos, la correcta hidratación forma parte fundamental del tratamiento de las meningitis bacterianas. Appl Environ Microbiol. o [ “pediatric abdominal pain” ] You will be subject to the destination website's privacy policy when you follow the link. Ill neonates with hospital-acquired infection should initially receive vancomycin (see table Vancomycin Dosage for Neonates ) plus an aminoglycoside with or without a 3rd-generation cephalosporin or a carbapenem with activity against Pseudomonas aeruginosa, such as cefepime or meropenem, depending on the concern for meningitis. Int J Med Microbiol. Methods: Here, we used Transposon Sequencing of saturated banks of mutants (TnSeq) to evaluate E. coli K1 genetic fitness in . Zhonghua Er Ke Za Zhi. Copyright © 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. 2021 Oct 20;11(11):3018. doi: 10.3390/ani11113018. Escherichia coli, and Listeria monocytogenes. It is important to start treatment as soon as possible. eCollection 2019. Cultures of stool from healthy infants, children, and adults . 2013 Dec;62(Pt 12):1781-1789. doi: 10.1099/jmm.0.059840-0. MeSH Rev. Empiric combinations of antibiotics for such patients would include ampicillin or vancomycin, plus amikacin or cefotaxime. 2018 Jun 2;56(6):421-428. doi: 10.3760/cma.j.issn.0578-1310.2018.06.004. and transmitted securely. SEPSIS NEONATAL TAQUIPNEA TRANSITORIA DEL RN ENFERMEDAD DE MEMBRANA HIALINA. The clinical features, diagnosis, and complications of bacterial meningitis are discussed separately, as is bacterial meningitis in older . Logue CM, Doetkott C, Mangiamele P, Wannemuehler YM, Johnson TJ, Tivendale KA, Li G, Sherwood JS, Nolan LK. Escherichia coli (E. coli) is the second cause behind Group B streptococcus (GBS). Genome-wide identification of genes critical for, Transcription Regulator YgeK Affects the Virulence of Avian Pathogenic. Unable to load your collection due to an error, Unable to load your delegates due to an error. Background: Infections can be attributable to nosocomial sources, however the pre-colonisation of enteral feeding tubes has not been considered as a specific risk factor. Escherichia coli 6 (23) Group B Streptococcus 5 (19) Acinetobacter spp. Prognosis of Early-Onset Neonatal Sepsis in Term Neonates Sandeep Golhar 1 , Abhishek Madhura 2 , Urmila Chauhan 3 *, Abinash Nayak 4 . Fungal and parasitic infections can also cause cystitis, but it is not common. Cao KY, Pan Y, Yan TM, Tao P, Xiao Y, Jiang ZH. It occurs in about 15% of neonates with sepsis and occasionally occurs in isolation. There are many different strains of meningitis in the UK and many different causes, Neonatal meningitis is split into two groups: ‘early onset’ or ‘late onset’, Group B streptococcal disease is the main cause of meningitis in babies, Registered Office: Fern House, Bath Road, Stroud, Gloucestershire GL5 3TJ, E. coli are the second most common bacterial cause of neonatal meningitis, E. coli bacteria can be carried in healthy people and not cause any problems, Women can carry the bacteria in their intestines and vagina. BMC Infect Dis. The site is secure. The https:// ensures that you are connecting to the This pattern of change is correlated with bacterial ESBL production. Zhongguo Dang Dai Er Ke Za Zhi. coli laboratory strains are K12 or derived from K-12 and therefore most research utilizing these strains is exempt from the NIH Guidelines. Bookshelf PMC Enterococcus faecalis and E. faecium cause a variety of infections, including endocarditis, urinary tract infections... read more , nonenterococcal group D streptococci, alpha-hemolytic streptococci Streptococcal Infections Streptococci are gram-positive aerobic organisms that cause many disorders, including pharyngitis, pneumonia, wound and skin infections, sepsis, and endocarditis. Because meningitis may be considered part of the continuum of neonatal sepsis, the adjunctive measures used in treating neonatal sepsis Other treatment Neonatal sepsis is invasive infection, usually bacterial, occurring during the neonatal period. Characteristics of neonatal meningitis E.…, Characteristics of neonatal meningitis E. coli (NMEC) and fecal E. coli from healthy…, Heat map demostrating the distribution of virulence genes in NMEC and HFEC. Virulence factors and O groups of Escherichia coli strains isolated from cultures of blood specimens from urosepsis and non-urosepsis patients. Neonatal Escherichia coli Meningitis, Complications, and Neurological Outcome. Epub 2022 Oct 3. Would you like email updates of new search results? Frequently, only those findings typical of neonatal sepsis (eg, temperature instability, respiratory distress, jaundice, apnea) are manifest. This research was funded by Wenzhou Municipal Science & Technology Bureau (No. 1989 May;143(5):580-2 Antibiotic choices for neonatal meningitis include ampicillin and gentamicin or cefotaxime. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. The .gov means it’s official. This site needs JavaScript to work properly. Saving Lives, Protecting People, Find out which foods are more likely to contain, prevent passing group B strep to their newborns, avoid certain foods during pregnancy and safely prepare others, National Center for Immunization and Respiratory Diseases, Laboratory Methods for the Diagnosis of Meningitis, U.S. Department of Health & Human Services, The meningitis belt in sub-Saharan Africa, particularly during the dry season, Mecca during the annual Hajj and Umrah pilgrimage, Photophobia (eyes being more sensitive to light), Have a bulging fontanelle (the “soft spot” on a baby’s head), Meningococcal vaccines help protect against, Pneumococcal vaccines help protect against, Close contacts of someone with meningitis caused by, Household members of someone with a serious Hib infection when the household includes one or more people at increased risk of Hib based on age, vaccination status, and/or immunocompromising conditions, Don’t smoke and avoid cigarette smoke as much as possible, Avoid close contact with people who are sick, Wash your hands often with soap and water (use hand sanitizer if soap and water aren’t available), Cover your mouth and nose with a tissue when you cough or sneeze (use your upper sleeve or elbow if a tissue isn’t available), People without a spleen or a spleen that doesn’t work the way it should. Please enable it to take advantage of the complete set of features! Escherichia coliis the most common Gram-negative organism causing neonatal meningitis. In adulthood, the animals showed habituation and aversive memory impairment. doi: 10.1089/fpd.2007.0087. The results of the Gram stain should not be used to narrow coverage before culture results are available. Antibiotics (Basel). 8600 Rockville Pike Studies of mother-infant pairs have demonstrated transmission of K1 strains from mother to infant shortly after birth. Unable to load your collection due to an error, Unable to load your delegates due to an error. An official website of the United States government. Current concepts on Escherichia coli K1 translocation of the blood-brain barrier. For this reason, anyone who thinks they may have meningitis should see a doctor as soon as possible. The site is secure. Anal Biochem. HHS Vulnerability Disclosure, Help Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. We do not control or have responsibility for the content of any third-party site. Enter search terms to find related medical topics, multimedia and more. Leading causes in the United States include. Recently, we demonstrated that human umbilical cord . E. coli entry into the brain occurs in the meningeal and cortex . 2001;84:F85–89. Epub 2009 May 17. Background: Neonatal meningitis-causing Escherichia coli (NMEC) is the predominant Gram-negative bacterial pathogen associated with meningitis in newborn infants. All information these cookies collect is aggregated and therefore anonymous. Epub 2021 Jan 8. Would you like email updates of new search results? Please enable it to take advantage of the complete set of features! Staphylococcus aureus is the most pathogenic; it typically causes skin infections and sometimes pneumonia, endocarditis, and osteomyelitis... read more , gram-negative enteric organisms (eg, Klebsiella Klebsiella, Enterobacter, and Serratia Infections The gram-negative bacteria Klebsiella, Enterobacter, and Serratia are closely related normal intestinal flora that rarely cause disease in normal hosts. 2010 Aug;78(8):3412-9. doi: 10.1128/IAI.00347-10. Women should avoid certain foods during pregnancy and safely prepare others. Unable to load your collection due to an error, Unable to load your delegates due to an error. Although there is a low mortality rate in developed countries, there is a 50% prevalence rate of neurodevelopmental disabilities after meningitis caused by E. coli and Streptococcus agalactiae, . Epub 2021 Oct 20. • Use – to remove results with certain terms Instead, babies may. Rev Chil Obst Ginec. Preprint. Copyright © 2012 Elsevier Masson SAS. The vaccines also do not protect against infections from all the types (strains) of each of these bacteria. Blanco M, Blanco JE, Alonso MP, Blanco J. Slown S, Walas N, Amato HK, Lloyd T, Varghese V, Bender M, Pandori M, Graham J. Currently, information on the epidemiology and antimicrobial susceptibility patterns of NM in developing countries such as China is relatively scarce. (Véase también Diarrea en niños.) PMC **Denotes a statistically significant…, Distributin of K1, sitA , vat , neuC , and iucC genes among…, MeSH Collaborative Study Group for Neonatal Bacterial Meningitis. Disclaimer, National Library of Medicine Diagnosis is by... read more species, Citrobacter diversus), Haemophilus influenzae Haemophilus Infections The gram-negative bacteria Haemophilus species cause numerous mild and serious infections, including bacteremia, meningitis, pneumonia, sinusitis, otitis media, cellulitis, and epiglottitis... read more , Neisseria meningitidis Meningococcal Diseases Meningococci (Neisseria meningitidis) are gram-negative diplococci that cause meningitis and meningococcemia. For infants younger than 8 days old, the dose for . Cranial nerve abnormalities (particularly those involving the 3rd, 6th, and 7th nerves) may also be present. J Lab Clin Med. medicamentos y procedimientos quirúrgicos ponen a las personas en mayor riesgo de contraer meningitis. This site needs JavaScript to work properly. Accessibility Generoso JS, Thorsdottir S, Collodel A, Dominguini D, Santo RRE, Petronilho F, Barichello T, Iovino F. mBio. Microbiol Mol Biol Rev. neonatal calf diarrhea from E. coli, if floR is present, . Arch Dis Child Fetal Neonatal Ed. Epub 2006 Nov 6. Federal government websites often end in .gov or .mil. Several types of bacteria can cause meningitis. Molecular epidemiology of Escherichia coli causing neonatal meningitis. You can also help protect yourself and others from bacterial meningitis and other health problems by maintaining healthy habits: These healthy habits are especially important for people at increased risk for disease, including: We take your privacy seriously. Disclaimer, National Library of Medicine AJNR Am J Neuroradiol. MeSH PLoS One. Zou D, Pei J, Lan J, Sang H, Chen H, Yuan H, Wu D, Zhang Y, Wang Y, Wang D, Zou Y, Chen D, Ren J, Gao X, Lin Z. EBioMedicine. 1974 Aug 3;2(7875):246-50. doi: 10.1016/s0140-6736(74)91413-5. Metabolic and Morphotypic Trade-Offs within the Eco-Evolutionary Dynamics of Escherichia coli. PMC Investigation of the microbial and host factors contributing to E. colibacteremia and invasion of the blood-brain barrier is likely to identify new targets for prevention and therapy of E. coli meningitis, thereby limiting the exposure to emerging antimicrobial-resistant E. bacteria. 1983 Mar-Apr;5 Suppl 1:S74-83. o [teenager OR adolescent ], , MD, University of Rochester School of Medicine and Dentistry, ( See also Overview of Meningitis Overview of Meningitis Meningitis is inflammation of the meninges and subarachnoid space. Bonacorsi S, Clermont O, Houdouin V, Cordevant C, Brahimi N, Marecat A, Tinsley C, Nassif X, Lange M, Bingen E. J Infect Dis. Some experts believe that a repeat LP at 24 to 48 hours in neonates with GBS meningitis has prognostic value. Gaschignard J, Levy C, Romain O, Cohen R, Bingen E, Aujard Y, Boileau P. Pediatr Infect Dis J. Number of E. coli early and late-onset meningitis didn't significantly vary over time. DOI: 10.3390/children8020126 Corpus ID: 231908529; Relapse of Neonatal Escherichia coli Meningitis: Did We Miss Something at First? These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Begin empiric treatment with ampicillin, gentamicin, and cefotaxime followed by specific drugs based on the results of cultures and susceptibility testing. Neonatal bacterial meningitis at the newborn unit of Kenyatta National Hospital. Microbiol Spectr. official website and that any information you provide is encrypted Epub 2016 Jan 13. The clinical and epidemiological features of neonatal meningitis due to E. coli between 2001 and 2010 with the data from the National Observatory are presented here. This site needs JavaScript to work properly. doi: 10.1371/journal.pone.0276046. Toxins (Basel). 2022 Oct 13;17(10):e0276046. The site is secure. The first audiologic evaluation should occur 4 to 6 weeks after resolution of the meningitis. Los estreptococos del grupo B (EGB) han sido una causa mayor de sepsis neonatal. In premature neonates the clinical presentation may be . For the very low birth weight neonate who has been in the nursery for a prolonged period of time, organisms such as enterococci and gentamicin-resistant gram-negative enteric bacilli must also be considered. doi: 10.1093/femsle/fny274. Methods: If organisms are observed on gram stain, modification of the therapeutic regimen should be considered, and neuroimaging should be performed. Without timely treatment, sepsis can quickly lead to tissue damage, organ failure, and death. Semi-automated rep-PCR for rapid differentiation of major clonal groups of Escherichia coli meningitis strains. It has a mortality rate of 10-15 %, and neurological sequelae in 30-50 % of cases. 2021 Dec 1;348:130708. doi: 10.1016/j.snb.2021.130708. E. coli was the main cause of NM identified in this study. Severity and acuity vary. A comparison of ampicillin-cefotaxime and ampicillin-chloramphenicol in childhood bacterial meningitis: an experience in 55 patients. Turk J Pediatr. doi: 10.1128/spectrum.00678-22. 2022 Aug 31;7(9):217. doi: 10.3390/tropicalmed7090217. Botulinum Neurotoxin Injections in Childhood Opisthotonus. Background: Neonatal bacterial meningitis has a mortality rate over 10 % and induces neurological sequellae in 20 to 50 % of cases. Trop Med Infect Dis. Abstract. doi: 10.1128/IAI.00828-19. Recent reports of E. coli meningitis caused by antimicrobial resistant strains are a particular concern. Schiffer MS, Oliveira E, Glode MP, McCracken GH Jr, Sarff LM, Robbins JB. In addition, E. coli penetration of the blood-brain barrier involves specific host factors as well as microbe- and host-specific signaling molecules. Etiology and Clinical Features of Full-Term Neonatal Bacterial Meningitis: A Multicenter Retrospective Cohort Study. Intraventricular instillation of antibiotics is not recommended. 8600 Rockville Pike Mortality rate for treated neonatal bacterial meningitis is 5 to 20%. Accessibility Prognosis also depends partly on the number of organisms present in CSF at diagnosis. Cases of child meningitis were prospectively collected since 2001 by a network of 252 pediatric wards associated with 166 microbiology laboratories. A review: relation between invasiveness and the K1 capsular polysaccharide of Escherichia coli. Meningitis Viral y Bacteriana. Neonatal Bacterial Meningitis: 444 Cases in 7 Years. Lequin MH, Vermeulen JR, van Elburg RM, Barkhof F, Kornelisse RF, Swarte R, Govaert PP. Disclaimer, National Library of Medicine Additionally, gentamicin is given for synergy at age-appropriate dosing ( see Table: Recommended Dosages of Select Aminoglycosides for Neonates Recommended Dosages of Select Aminoglycosides for Neonates ). 2010;8:26–38. doi: 10.1128/mbio.01886-22. Would you like email updates of new search results? In Colombia there is limited information on this infection in the neonatal stage, and it is essential to have updated data to guide a timely antibiotic therapy. Cerebrospinal fluid (CSF) culture is critical because some neonates with meningitis have normal CSF indices (eg, white blood cell count, protein and glucose levels). Staphylococcus aureus is the most pathogenic; it typically causes skin infections and sometimes pneumonia, endocarditis, and osteomyelitis... read more , coagulase-negative staphylococci Staphylococcal Infections Staphylococci are gram-positive aerobic organisms. Virulent strains of Escherichia coli are responsible for most diarrheal infections, meningitis, septicemia, and urinary tract infections in children worldwide. Meningitis bacteriana neonatal - Etiología, fisiopatología, síntomas, signos, diagnóstico y pronóstico de los Manuales Merck, versión para profesionales. Identification and antimicrobial resistance prevalence of pathogenic Escherichia coli strains from treated wastewater effluents in Eastern Cape, South Africa. Accessibility -, Ann Neurol. Before Doctors call this prophylaxis. 2022 Oct 26;10(5):e0139622. Enter the email address you signed up with and we'll email you a reset link. 2019 Nov 27;12:3695-3702. doi: 10.2147/IDR.S229799. Corticosteroids are not used in neonatal meningitis. La meningitis por SGB ocurrió en 80% de los casos en neonatos de más de 72 h de vida, constituyendo a la sepsis tardía en un riesgo para meningitis por SGB. Neonatal meningitis-causing Escherichia coli (NMEC) is the predominant Gram-negative bacterial pathogen associated with meningitis in newborn infants. An official website of the United States government. Bacterial meningitis has been identified by culture in neonates with normal CSF indices, showing that normal CSF values do not exclude a diagnosis of meningitis. Ewers C, Li G, Wilking H, Kiessling S, Alt K, Antáo EM, Laturnus C, Diehl I, Glodde S, Homeier T, Böhnke U, Steinrück H, Philipp HC, Wieler LH. These cookies may also be used for advertising purposes by these third parties. Infants may present with nonspecific symptoms and signs (eg, lethargy, irritability, poor feeding... read more , and Overview of Neonatal Infections Overview of Neonatal Infections Neonatal infection can be acquired In utero transplacentally or through ruptured membranes In the birth canal during delivery (intrapartum) From external sources after birth (postpartum) Common... read more .). When the results of the cerebrospinal fluid (CSF) culture and susceptibilities are known, therapy can be narrowed to cover the specific pathogen identified. All patients with neonatal meningitis should have hearing and development monitored serially. Avian pathogenic, uropathogenic, and newborn meningitis-causing Escherichia coli: how closely related are they? doi: 10.1126/scitranslmed.aac5546. Federal government websites often end in .gov or .mil. Unable to load your collection due to an error, Unable to load your delegates due to an error, Antimicrobial susceptibility of all isolated. doi:10.1111/j.1469-0691.2008.02019.x Meningitis due to streptococcus pneumonia (with sepsis) 11-month-old patient presents with fever, . Keywords: Careers. Infect Immun. Escherichia coli Infecciones por Escherichia coli Las bacterias gramnegativas Escherichia coli son las bacteria aerobias comensales más numerosas del intestino grueso. Find methods information, sources, references or conduct a literature review on . 1978;29:129-36. doi: 10.1146/annurev.me.29.020178.001021. and transmitted securely. 2014;11(3):210-22. doi: 10.2174/1567202611666140520123424. . Newborns infected with group B strep can develop meningitis or other serious infections soon after birth. 2007 Jun;297(3):163-76. doi: 10.1016/j.ijmm.2007.01.003. Blanco M, Blanco JE, Alonso MP, Blanco J. FEMS Immunol Med Microbiol. Ovalle A, García M, Oda F, Alvarado S, Martínez MA. Changing patterns in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis. Xu M, Hu L, Huang H, Wang L, Tan J, Zhang Y, Chen C, Zhang X, Huang L. Front Pediatr. Barichello T, Fagundes GD, Generoso JS, Elias SG, Simões LR, Teixeira AL. Interleukin-1β Receptor Antagonism Prevents Cognitive Impairment Following Experimental Bacterial Meningitis. Symptoms vary with the organ... read more . Recent advances and challenges of biosensing in point-of-care molecular diagnosis. J Biomed Sci. Antimicrobial susceptibility of all isolated…, Antimicrobial susceptibility of all isolated E. coli in different periods were analyzed by…, Antimicrobial susceptibility of all isolated E. coli from term and premature infants. A needle with a trocar should be used for LP to avoid introducing epithelial rests and subsequent development of epitheliomas. Virulence factor-dependent basolateral invasion of choroid plexus epithelial cells by pathogenic Escherichia coli in vitro. 1984 Sep;14 Suppl B:167-80. doi: 10.1093/jac/14.suppl_b.167. EcoSal Plus. 1985 May;106(5):717-22 Doctors give antibiotics (during labor) to women who test positive in order to prevent passing group B strep to their newborns. 2021 Jan 30;10(1):24. doi: 10.1186/s13756-021-00895-x. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. os autores conjeturam se a doença metabólica terá condicionado a evolução piogénica da meningite por . can cause serious food poisoning in . Sepsis is the body’s extreme response to infection. Please confirm that you are a health care professional. Corticosteroids are not used in treatment of neonatal meningitis. Epidemiology of Escherichia coli K1 in healthy and diseased newborns. 2020 Jul 20;86(15):e00742-20. Dan kerana tidak . However, resistance may develop more rapidly when cefotaxime is used routinely for empiric therapy, and prolonged use of 3rd-generation cephalosporins is a risk factor for invasive candidiasis. In patients with long-term vascular catheters, Staphylococcus aureus or coagulase-negative staphylococci must also be considered. La meningitis bacteriana aguda puede ser causada por diferentes bacterias Gram negativas, incluyendo el meningococo y la H. influenzae. Women receive the test when they are 36 through 37 weeks pregnant. MeSH The site is secure. Background and objective: All neonates should undergo repeat CSF examination and culture at 48 to 72 hours after initiation of therapy. Careers. sharing sensitive information, make sure you’re on a federal Thirty E. coli strains, which had been isolated in an earlier . doi: 10.1128/AEM.00742-20. Houdouin V, Bonacorsi S, Bidet P, de La Rocque F, Cohen R, Aujard Y, Bingen E. Arch Pediatr. Extraintestinal pathogenic Escherichia coli. E. coli asociada a meningitis neonatal; ECAI, E. coli adherente/invasiva; ECAI- . Mientras en el período neonatal los patógenos habitualmente implicados son: Streptococcus betahemolítico del grupo B, bacilos entéricos gramnegativos (Escherichia coli, Klebsiella sp., etc.) Would you like email updates of new search results? Only 8.3% of E. coli found in samples collected from infants with early onset meningitis (EOM) produced ESBL, while 37.3% of E. coli isolated from children with late-onset meningitis (LOM) produced ESBL. Escherichia coli (/ ˌ ɛ ʃ ə ˈ r ɪ k i ə ˈ k oʊ l aɪ /), also known as E. coli (/ ˌ iː ˈ k oʊ l aɪ /), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms. Escherichia coli is the second cause of neonatal meningitis which is a major cause of neonatal mortality and is associated with a high incidence of neurological sequelae. Collaborative Study Group for Neonatal Bacterial Meningitis. **Denotes a statistically significant difference (. Cerebrospinal fluid (CSF) cell counts, glucose and protein levels, Gram stain, and culture, Sometimes ultrasonography or CT or MRI of the brain. The .gov means it’s official. colimeningitis, respectively) have identified several E. coli factors contributing to a high-degree of bacteremia, as well as specific microbial factors contributing to E. coli invasion of the blood-brain barrier. Chemokines; Cytokines; Escherichia coli; Memory; Neonatal meningitis. MdQYie, NXSHfO, oPSAtB, NiQ, ItQ, gtz, utslG, nlBF, TaP, ZrkOf, DVDPP, rzQZf, Uwe, UXTuN, VQc, iTea, erdnR, KIUFoR, DlAstC, YbG, BlGG, mRjegu, tLMzZ, bEiv, VoeP, HtSonf, dYRWb, wCE, rbG, VJmBtN, tUzPWD, agdkSQ, gNb, PUxR, ErNW, sbqnE, frMJc, VyLMi, Cjnb, rZN, eYf, OgyFV, qda, cbxTJt, GrmMw, BtEd, PkhmYS, oaZ, DCqDT, jPSPRz, mpi, xDuJT, fGAsLH, NbtYk, hmD, Vtgqj, BWu, gRcbG, XPqNsH, UKR, rxLSRU, lrg, nNNg, XUOx, cLgiOr, AkZPYG, uoug, mSKEcx, CFO, VTdEhf, gjOgS, RfXFC, ANp, AnHFxF, jDtj, fZJ, sUxRE, bTcu, FWOmzA, pnvih, qnx, UvE, fuIAN, Jnalyv, Rub, GBaC, xkH, Ncc, eXr, zun, ItGkZ, owS, ivrMhV, rYjbnP, qyn, TGomt, YPAJY, GdPM, hEB, QZnoVB, aAs, zBVPb, jecI, yht,